ketoconazole prostate cancer
Prostate Cancer Treatment (PDQ®) - National Cancer Institute
Sep 21, 2012 . Chemotherapy for Hormone-Refractory Prostate Cancer . [36] Survival rates are similar whether ketoconazole plus hydrocortisone is initiated .
http://www.cancer.gov/cancertopics/pdq/treatment/prostate/HealthProfessional/page9High Dose Ketoconazole (Nizoral) Plus Hydrocortisone - HRPCa
The focus here is on HDK. High Dose Ketoconazole(HDK). In cases where prostate cancer (PCa) is not considered treatable with a prostatectomy or radiation, .
http://www.hrpca.org/HDK.htmlSponsor:
ketoconazole :: Malecare's Advanced Prostate Cancer
May 10, 2012 . The use of Ketoconazole (Keto) in men with advanced prostate cancer is not considered mainstream, however there is clear evidence that it .
http://advancedprostatecancer.net/?cat=174Information provided by (Responsible Party):
Contemporary experience with ketoconazole in patients with ...
Jun 17, 2011 . Contemporary experience with ketoconazole in patients with metastatic castration-resistant prostate cancer: clinical factors associated with PSA .
http://www.ncbi.nlm.nih.gov/pubmed/21688281Ketoconazole in Taiwanese castration-resistant prostate cancer ...
To evaluate the efficacy of ketoconazole in castration-resistant prostate cancer. We reviewed the medical records of consecutive patients with pathologically con.
http://www.sciencedirect.com/science/article/pii/S1879522612000310NCT00895310
Ketoconazole - Wikipedia, the free encyclopedia
Due to its efficacy at reducing systemic androgen levels, ketoconazole has been used as a treatment for androgen-dependent prostate cancer. Second .
http://en.wikipedia.org/wiki/KetoconazoleA new way to treat prostate cancer: The story of abiraterone
Sep 10, 2012 . The team started with a drug called ketoconazole, which they noticed prevented the growth of prostate cancer cells. The drug worked by .
http://www.icr.ac.uk/press/recent_featured_articles/Story_Abiraterone/index.shtmlLast verified: June 2012
Purpose
Efficacy of ketoconazole in castration-refractory prostate cancer: A ...
T. J. Fillos, D. Chu, S. Wu. Abstract Disclosures. Abstract: Introduction: Ketoconazole in combination with hydrocortisone has been used in the treatment of .
http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=54&abstractID=20076
Use of Low Dose Ketoconazole in Prostate Cancer - ClinicalTrials.gov
Jun 29, 2012 . The purpose of this study is to test the safety of ketoconazole and how well it works after chemotherapy has been used. Ketoconazole at lower .
http://clinicaltrials.gov/ct2/show/NCT00895310| kenmore 110 manual combo | kelly clarkson miss independent lyric | kenia viva cuba 8th street latinas |
|---|---|---|
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Prostate Cancer |
Drug: Ketoconazole |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Endpoint Classification: Safety/Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Supportive Care |
| Official Title: | Assessing PSA Response in Low Dose Ketoconazole in Hormone Refractory Prostate Cancer Patients Who Have Failed at Least One Prior Systemic Chemotherapy Regimen |
Resource links provided by NLM:
Ketoconazole: From an antimycotic to a drug for prostate cancer
Key words: sex steroids, ketoconazole, prostate cancer. INTRODUCTION. Ketoconazole is an oral antifungal imidazole derivative that is active against a broad .
http://onlinelibrary.wiley.com/doi/10.1002/ddr.430080134/pdfPrimary Outcome Measures:
Chemoregimen - Prostate Cancer
Antiandrogen withdrawl alone or in combination with ketoconazole in androgen- independent prostate cancer patients: a phase III trial (CALGB 9583).http://chemoregimen.com/Prostate-Cancer-c-51-61.html
Secondary Outcome Measures:
Lupron and Casodex and Now Provenge? Ketoconazole? Zytiga ...
My husband has been battling prostate cancer since January of 2004. Had radical prostatectomy in April 2004. April 2005, had recurrence .http://www.inspire.com/groups/us-too-prostate-cancer/discussion/lupron-and-casodex-and-now-provenge-ketoconazole-zytiga/
| Estimated Enrollment: | 30 |
| Study Start Date: | May 2009 |
| Estimated Study Completion Date: | December 2013 |
| Estimated Primary Completion Date: | December 2012 (Final data collection date for primary outcome measure) |
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| Experimental: Ketoconazole |
Drug: Ketoconazole
High Dose Ketoconazole Plus Hydrocortisone - Prostate Cancer ... High-dose ketoconazole (HDK) is an oral broad-spectrum anti-prostate cancer ( PC) agent that has testosterone lowering effects through its abilities to decrease . http://prostate-cancer.org/high-dose-ketoconazole-plus-hydrocortisone-hdk-hc/Other Name: Nizoral
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High-dose ketoconazole in advanced hormone-refractory prostate ...
While ketoconazole with hydrocortisone does suppress plasma androgens in advanced prostatic cancer patients, this infrequently causes regression of cancer .
http://jco.ascopubs.org/content/7/8/1093
PROSTATE CANCER COMMUNICATION HIGH DOSE ...
Sep 3, 2010 . high dose (800-1200 mg) ketoconazole (HDK) was effective against prostate cancer even after the development of hormone resistance.
http://paactusa.org/uploads/Sept2010_9329.pdf
Funding from PCCTC Advances Study of Ketoconazole and Docetaxel
June 3, 2012—Ketoconazole (keto) is drug used in prostate cancer to block the release of testosterone from the adrenal glands, typically administered in .
http://www.pcf.org/site/c.leJRIROrEpH/b.8102739/k.D98D/Funding_from_PCCTC_Advances_Study_of_Ketoconazole_and_Docetaxel_Response_Following_Abiraterone_Acetate.htm
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
Ketoconazole: MedlinePlus Drug Information
A small number of patients who were taking high doses of ketoconazole for prostate cancer died soon after they began taking the medication. It is not known .http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682816.htmlHow is ketoconazole used to treat prostate cancer? - Sharecare
How is the antifungal ketoconazole used to treat prostate cancer? In very high doses, the antifungal ketoconazole rapidly lowers blood levels of testosterone .http://www.sharecare.com/question/how-ketoconazole-treat-prostate-cancer- Patients must be >18 years old
- Patients must have received at least one prior chemotherapy regimen >3 weeks prior to initiation of study and patients must have recovered from the side effects of the therapy
- Patients must have an ECOG status of 0-3
Secondary endocrine therapies for castration resistant prostate cancer
Aug 9, 2012 . Antiandrogen withdrawal alone or in combination with ketoconazole in androgen -independent prostate cancer patients: a phase III trial .http://www.uptodate.com/contents/secondary-endocrine-therapies-for-castration-resistant-prostate-cancerThe treatment of advanced prostate cancer with ketoconazole: safety ...
The treatment of advanced prostate cancer with ketoconazole: safety issues. Bok RA, Small EJ. University of California, San Francisco, 94143, USA.http://www.ncbi.nlm.nih.gov/pubmed/10348095- Patients must have a serum total testosterone level <50 ng/dl
Ketoconazole retains activity in patients with docetaxel-refractory ...
The activity of ketoconazole in this clinical state has not previously been . ketoconazole in patients with castration-resistant metastatic prostate cancer who had .http://annonc.oxfordjournals.org/content/20/5/965.2.fullKETOCONAZOLE (HIGH DOSE/HDK ... - The Prostate Advocate
KETOCONAZOLE (HIGH DOSE/HDK) GUIDELINES. (Compiled by Charles ( Chuck) Maack – Prostate Cancer Advocate). Disclaimer: Please recognize that I am .http://www.theprostateadvocate.com/pdf/KETOCONAZOLE.pdf
Exclusion Criteria:
- Patients with any condition that impairs the ability to swallow medications orally
- Patients who are unable to give informed consent
- Patients who have received ketoconazole treatment for prostate cancer in the past
- Patients with other active malignancies in the past 3 years except nonmelanoma skin cancer
- Patients may not be receiving any other investigational agents
- Patients with known hypersensitivity to ketoconazole
Abiraterone Acetate and Ketoconazole in Prostate Cancer Patients ...
Aug 22, 2011 . Chicago—A study of patients with progressive metastatic castration-resistant prostate cancer (mCRPC) who had previously used ketoconazole .http://www.firstreportnow.com/articles/abiraterone-acetate-and-ketoconazole-prostate-cancer-patients
Contacts and LocationsMARY and JOHN'S story « Prostablog
The partner of a Kiwi man battling prostate cancer tells her story MARY is the partner . The bad news is that it looks like Ketoconazole is off the prostate cancer .
http://prostablog.wordpress.com/older-stuff/prostate-stories/mary-johns-prostate-saga/Contacts
Efficacy of Low-dose Ketoconazole in Hormone Refractory Prostate ... 36 No. 10. 811. Efficacy of Low-dose Ketoconazole in HRPC—Lynette SM Ngo et al. Efficacy of Low-dose Ketoconazole in Hormone Refractory Prostate Cancer . http://www.annals.edu.sg/pdf/36VolNo10Oct2007/V36N10p811.pdf |
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EFFICACY OF KETOCONAZOLE IN HORMONE REFRACTORY ... This study aims to describe our experience with ketoconazole treatment for hormone refractory prostate cancer (HRPC) at our centre. Retrospective chart review . http://www.banglajol.info/index.php/JOM/article/download/2814/2330 |
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Locations
An Evaluation of Intermediate-Dose Ketoconazole in Hormone ... An Evaluation of Intermediate-Dose Ketoconazole in Hormone Refractory Prostate Cancer. Simon Wilkinson, Gerald Chodak. Accepted 26 November 2003 , . http://www.europeanurology.com/article/S0302-2838(03)00677-8/abstract | |
Prostate Oncology Specialists - Glossary Subsequently it was discovered that high dose Ketoconazole (HDK) is effective against prostate cancer even after the development of hormone resistance. http://www.prostateoncology.com/education/glossary/a:2d_hormonal_therapy |
Recruiting |
About Dosing Ketoconazole - Malecare's Advanced Prostate Cancer Feb 3, 2011 . There are two different dosage levels used for the administration of Ketoconazole (Keto), a commonly used 2nd line hormone deprivation drug . http://advancedprostatecancer.net/?p=2318 | |
Ketoconazole retains activity in advanced prostate cancer patients with MATERIALS AND METHODS: A total of 50 consecutive patients with advanced prostate cancer received ketoconazole and hydrocortisone at progression after . http://www.ncbi.nlm.nih.gov/pubmed/9120902 | |
Sponsors and Collaborators
Long-term outcome for men with androgen independent prostate ...
PURPOSE: The combination of high dose ketoconazole and hydrocortisone ( HDK) is active against androgen independent prostate cancer (AIPC). Median .
http://www.ncbi.nlm.nih.gov/pubmed/15879788Investigators
| Principal Investigator: | High-dose ketoconazole in castration-resistant, metastatic prostate ... High-dose ketoconazole in castration-resistant, metastatic prostate cancer patients previously treated with docetaxel chemotherapy: Single institution . http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=74&abstractID=54662 |
Efficacy of low-dose ketoconazole in hormone refractory prostate ... Efficacy of low-dose ketoconazole in hormone refractory prostate cancer patients at the National Cancer Centre and The Cancer Institute, Singapore. Ngo LS . http://www.ncbi.nlm.nih.gov/pubmed/17987231 |
More Information
No publications provided
| Responsible Party: | Activity of dutasteride plus ketoconazole in castration-refractory ... BACKGROUND: Ketoconazole is a commonly used secondary hormonal therapy in castration-refractory prostate cancer (CRPC), but disease progression . http://www.ncbi.nlm.nih.gov/pubmed/19815488 |
Indications for use of ketoconazole in management of metastatic ... Indications for use of ketoconazole in management of metastatic prostate cancer. Lowe FC, Bamberger MH. Department of Urology, St. Luke's/Roosevelt . http://www.ncbi.nlm.nih.gov/pubmed/2247927 |
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| Other Study ID Numbers: | Rationale for combination ketoconazole/ vitamin D treatment of ... Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer. Peehl DM, Seto E, Feldman D. Department of Urology, Stanford University . http://www.ncbi.nlm.nih.gov/pubmed/11502466 |
| Study First Received: | May 6, 2009 |
| Last Updated: | June 29, 2012 |
| Health Authority: | United States: Institutional Review Board |
Low dose ketoconazole with replacement doses of hydrocortisone in ...
oral ketoconazole 3 times daily with replacement doses of hydrocortisone has become a standard treatment option for patients with advanced prostate cancer .
http://www.ncbi.nlm.nih.gov/pubmed/12131305|
PSA Ketoconazole Prostate Cancer Hormone Refractory Chemotherapy Regimen |
Additional relevant MeSH terms:
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Prostatic Neoplasms Ketoconazole and Dexamethasone in Prostate Cancer - Full Text ... Mar 19, 2012 . This is an open label, phase II, single center trial of ketoconazole/ dexamethasone to determine if the administration of . http://clinicaltrials.gov/ct2/show/NCT01036594Urogenital Neoplasms Neoplasms by Site Neoplasms Activity of dustasteride plus ketoconazole in hormone-refractory ... Introduction: Ketoconazole is commonly used as a secondary hormonal therapy in patients with hormone-refractory prostate cancer (HRPC), but disease . http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=46&abstractID=20212Prostatic Diseases Hormones Ketoconazole |
Activity of ketoconazole after taxane-based chemotherapy in ... Oct 23, 2009 . Activity of ketoconazole after taxane-based chemotherapy in castration-resistant prostate cancer. Nakabayashi M, Oh WK, Jacobus S, Regan . http://www.ncbi.nlm.nih.gov/pubmed/19863532Physiological Effects of Drugs Pharmacologic Actions 14-alpha Demethylase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Antifungal Agents Anti-Infective Agents Therapeutic ketoconazole prostate cancers |
Metastatic and Advanced Prostate Cancer
Sep 27, 2012 . Prostate cancer is the second leading cause of cancer-related deaths in . Most prostate cancer–related deaths are due to advanced disease, .
http://emedicine.medscape.com/article/454114-overview
